Simplified phenotyping of CYP2D6 for tamoxifen treatment using the N-desmethyl-tamoxifen/ endoxifen ratio

Introduction: CYP2D6 protein activity can be inferred from the ratio of N-desmethyl-tamoxifen (NDMT) to endoxifen (E). CYP2D6 polymorphisms are common and can affect CYP2D6 protein activity and E level. Some retrospective studies indicate that E < 16 nM may relate to worse outcome. Materials and met...

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Váldodahkkit:	Clara Inkyung Lee, Siew Kee Low, Ricardo Maldonado, Peter Fox, Bavanthi Balakrishnar, Sally Coulter, Peter de Bruijn, Stijn L.W. Koolen, Bo Gao, Jodi Lynch, Nicholas Zdenkowski, Rina Hui, Christopher Liddle, Ron H.J. Mathijssen, Nicholas Wilcken, Mark Wong, Howard Gurney
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Elsevier 2020-12-01
Ráidu:	Breast
Fáttát:	Tamoxifen Metabolism CYP2D6 Phenotype Endoxifen
Liŋkkat:	http://www.sciencedirect.com/science/article/pii/S0960977620301995
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