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Direct interaction of TrkA/CD44v3 is essential for NGF-promoted aggressiveness of breast cancer cells

Abstract Background CD44 is a multifunctional membrane glycoprotein. Through its heparan sulfate chain, CD44 presents growth factors to their receptors. We have shown that CD44 and Tropomyosin kinase A (TrkA) form a complex following nerve growth factor (NGF) induction. Our study aimed to understand...

Täydet tiedot

Tallennettuna:
Päätekijät: Sarah Trouvilliez, Julien Cicero, Romain Lévêque, Léo Aubert, Cyril Corbet, Alexandre Van Outryve, Karolin Streule, Pierre-Olivier Angrand, Pamela Völkel, Romain Magnez, Guillaume Brysbaert, Caroline Mysiorek, Fabien Gosselet, Roland Bourette, Eric Adriaenssens, Xavier Thuru, Chann Lagadec, Jérôme de Ruyck, Véronique Orian-Rousseau, Xuefen Le Bourhis, Robert-Alain Toillon
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BMC 2022-03-01
Sarja:Journal of Experimental & Clinical Cancer Research
Aiheet:
CD44v3
TrkA
NGF
Breast cancer
Metastasis
Linkit:https://doi.org/10.1186/s13046-022-02314-4
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