Antibody-recognizing residues 188-211 of TMEM106B exhibit immunohistochemical reactivity with the TMEM106B C-terminal fragment

Accumulation of TMEM106B fibrils composed of cleaved C-terminal fragments (CTF) of transmembrane protein 106B (TMEM106B) has recently been observed in the brains of elderly subjects and individuals with neurodegenerative diseases. To date, one antibody recognizing the residues 239-250 has been found...

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Principais autores:	Ruoyi Ishikawa, Yu Yamazaki, Masahiro Nakamori, Tetsuya Takahashi, Hirofumi Maruyama
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2023-10-01
Colecção:	Frontiers in Neuroscience
Assuntos:	TMEM106B C-terminal fragment fibrils new antibody neurodegenerative disease FTLD-MND
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fnins.2023.1250547/full
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