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Inducible deletion of CDK4 and CDK6 – deciphering CDK4/6 inhibitor effects in the hematopoietic system

Cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors are considered a breakthrough in cancer therapy. Currently approved for breast cancer treatment, CDK4/6 inhibitors are extensively tested in other cancer subtypes. Frequently observed side effects include hematological abnormalities such as reduc...

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Principais autores: Barbara Maurer, Tania Brandstoetter, Sebastian Kollmann, Veronika Sexl, Michaela Prchal-Murphy
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2020-08-01
coleção:Haematologica
Acesso em linha:https://haematologica.org/article/view/9918
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