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Using Metabolomics to Identify Cell Line-Independent Indicators of Growth Inhibition for Chinese Hamster Ovary Cell-Based Bioprocesses

Chinese hamster ovary (CHO) cells are widely used for the production of biopharmaceuticals. Efforts to improve productivity through medium design and feeding strategy optimization have focused on preventing the depletion of essential nutrients and managing the accumulation of lactate and ammonia. In...

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Principais autores: Nicholas Alden, Ravali Raju, Kyle McElearney, James Lambropoulos, Rashmi Kshirsagar, Alan Gilbert, Kyongbum Lee
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-05-01
coleção:Metabolites
Assuntos:
Chinese hamster ovary cell
untargeted metabolomics
tryptophan
5-hydroxyindoleacetaldehyde
growth inhibitor
Acesso em linha:https://www.mdpi.com/2218-1989/10/5/199
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