Pharmacological inhibition of toll-like receptor 4 suppresses ischemia-reperfusion injury-induced inflammation and improves lung allograft function after transplantation

Ischemia reperfusion injury (IRI) is a significant risk factor for primary graft dysfunction following lung transplantation. Toll-like receptor 4 (TLR4) signaling plays an important role not only in IRI but also in the development of acute and chronic allograft rejection. We investigated the therape...

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Principais autores:	Yasufumi Goda, MD, Mamoru Takahashi, MD, PhD, Itsuki Yuasa, MD, Yumeta Shimazu, MD, Naoki Date, MD, Satona Tanaka, MD, PhD, Hiroyuki Katsuragawa, MD, Akihiro Ohsumi, MD, PhD, Daisuke Nakajima, MD, PhD, Hiroshi Date, MD, PhD
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-11-01
coleção:	JHLT Open
Assuntos:	Toll-like receptor 4 Ischemia reperfusion injury Inflammation Lung transplantation Macrophage
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2950133425001946
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