A systematic literature review of MTAP deletions in solid and hematologic Cancers

Background: Methylthioadenosine phosphorylase (MTAP) deficiency is observed across multiple cancers and represents an emerging biomarker with therapeutic potential via synthetic lethality with PRMT5 inhibition. This systematic literature review summarizes the prevalence of MTAP deletions or loss of...

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Autors principals:	Mary C. Clouser, Mina Suh, Naimisha Movva, Janet S. Hildebrand, Susan T. Pastula, Martina Schoehl, Antreas Hindoyan, Akhila Balasubramanian, Jon P. Fryzek, Soo-Ryum Yang
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2025-01-01
Col·lecció:	Cancer Treatment and Research Communications
Matèries:	Cancer CDKN2A Co-mutations Homozygous deletions MTAP Survival
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2468294225001029
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