Ensemble model for neoadjuvant chemotherapy response prediction and treatment sensitivity in TNBC based on DNA replication stress signatures

Abstract Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer. Although neoadjuvant chemotherapy (NACT) has some effectiveness in TNBC, a portion of patients still do not benefit from them. The critical role of DNA replication stress (DRS) in cancer therapy has been r...

Description complète

Détails bibliographiques

Auteurs principaux:	Meishun Hu, Qifan Luo, Jun Li, Yanyan Chen, Mengting Chen, Zhuowan Tian, Lei Wei, Fangfang Chen, Jingwei Zhang
Format:	Artigo
Langue:	Inglês
Publié:	Nature Portfolio 2025-10-01
Collection:	Scientific Reports
Sujets:	TNBC Machine learning DNA replication stress Neoadjuvant chemotherapy
Accès en ligne:	https://doi.org/10.1038/s41598-025-21932-4
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!