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Porphyrin overdrive rewires cancer cell metabolism

Cancer cells exhibit a metabolic phenotype termed “porphyrin overdrive,” characterized by dysregulated heme metabolic pathways for intermediate accumulation. This rewiring is cancer-essential and cancer-specific. Targeting this vulnerability with a “bait-and-kill” strategy shows promise in eradicati...

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Autors principals: Swamy R Adapa, Gregory A Hunter, Narmin E Amin, Christopher Marinescu, Andrew Borsky, Elizabeth M Sagatys, Said M Sebti, Gary W Reuther, Gloria C Ferreira, Rays HY Jiang
Format: Artigo
Idioma:Inglês
Publicat: Life Science Alliance LLC 2024-07-01
Col·lecció:Life Science Alliance
Accés en línia:https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202302547
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