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LAG3 genotype of the donor and clinical outcome after allogeneic transplantation from HLA-identical sibling donors

IntroductionThe association of polymorphisms in molecules involved in the immune response (checkpoint inhibitors) with the clinical outcome after allogeneic transplantation (alloHSCT) has been described. Lymphocyte Activation 3 (LAG3) is a surface protein that plays a regulatory role in immunity as...

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Principais autores: David Cruz, Rocío Rodríguez-Romanos, Marta González-Bartulos, Irene García-Cadenas, Rafael de la Cámara, Inmaculada Heras, Ismael Buño, Nazly Santos, Natàlia Lloveras, Pilar Velarde, Esperanza Tuset, Carmen Martínez, Marcos González, Guillermo F. Sanz, Christelle Ferrá, Antonia Sampol, Rosa Coll, Jose A. Pérez-Simón, Javier López-Jiménez, Manuel Jurado, David Gallardo
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2023-01-01
coleção:Frontiers in Immunology
Assuntos:
LAG3: lymphocyte activation gene 3
graft-versus-host disease
allogeneic transplant
immune response
checkpoint molecules
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1066393/full
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