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ccf-mtDNA as a Potential Link Between the Brain and Immune System in Neuro-Immunological Disorders

Fragments of mitochondrial DNA (mtDNA) are released outside the cell and they appear to persist in extracellular fluids as circulating, cell-free, mtDNA (ccf-mtDNA). When compared to nuclear DNA, such a double stranded mtDNA is more resistant to nuclease degradation. In fact, it is stable extracellu...

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Autori principali: Stefano Gambardella, Fiona Limanaqi, Rosangela Ferese, Francesca Biagioni, Rosa Campopiano, Diego Centonze, Francesco Fornai
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019-05-01
Serie:Frontiers in Immunology
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Accesso online:https://www.frontiersin.org/article/10.3389/fimmu.2019.01064/full
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