The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition
<p>Abstract</p> <p>Background</p> <p>It has been shown in many solid tumors that the overexpression of the pro-survival Bcl-2 family members Bcl-xL and Mcl-1 confers resistance to a variety of chemotherapeutic agents. Mcl-1 is a critical survival protein in a variety of cell lineages and is critical...
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| Autors principals: | , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BMC
2012-11-01
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| Col·lecció: | BMC Cancer |
| Matèries: | |
| Accés en línia: | http://www.biomedcentral.com/1471-2407/12/541 |
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