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CMG901, a Claudin18.2-specific antibody-drug conjugate, for the treatment of solid tumors

Summary: Claudin18.2 has been recently recognized as a potential therapeutic target for gastric/gastroesophageal junction or pancreatic cancer. Here, we develop a Claudin18.2-directed antibody-drug conjugate (ADC), CMG901, with a potent microtubule-targeting agent MMAE (monomethyl auristatin E) and...

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I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Gang Xu, Wei Liu, Ying Wang, Xiaoli Wei, Furong Liu, Yanyun He, Libo Zhang, Qin Song, Zhiyao Li, Changyu Wang, Ruihua Xu, Bo Chen
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Elsevier 2024-09-01
Rangatū:Cell Reports Medicine
Ngā marau:
Urunga tuihono:http://www.sciencedirect.com/science/article/pii/S2666379124004312
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