Absence of parvalbumin increases mitochondria volume and branching of dendrites in inhibitory Pvalb neurons in vivo: a point of convergence of autism spectrum disorder (ASD) risk gene phenotypes

Abstract Background In fast firing, parvalbumin (PV)-expressing (Pvalb) interneurons, PV acts as an intracellular Ca2+ signal modulator with slow-onset kinetics. In Purkinje cells of PV−/− mice, adaptive/homeostatic mechanisms lead to an increase in mitochondria, organelles equally capable of delaye...

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Ngā kaituhi matua:	Lucia Janickova, Karin Farah Rechberger, Lucas Wey, Beat Schwaller
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	BMC 2020-06-01
Rangatū:	Molecular Autism
Ngā marau:	Parvalbumin Calcium-binding protein Mitochondria Calcium homeostasis Pvalb neurons Autism spectrum disorder
Urunga tuihono:	http://link.springer.com/article/10.1186/s13229-020-00323-8
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