Epigenetic silencing of miR-493 increases the resistance to cisplatin in lung cancer by targeting tongue cancer resistance-related protein 1(TCRP1)

Abstract Background The potential mechanisms regarding how methylation of microRNA(miRNA) CpG Island could regulate cancer cell chemo-resistance remains unclear. This study aims to explore the epigenetic dysregulation mechanism of miRNA-493 and the ability to modulate lung cancer cell chemotherapy r...

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Detalhes bibliográficos

Principais autores:	Yixue Gu, Zhijie Zhang, Jiang Yin, Jiahui Ye, Yin Song, Hao Liu, Yan Xiong, Minying Lu, Guopei Zheng, Zhimin He
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2017-08-01
Colecção:	Journal of Experimental & Clinical Cancer Research
Assuntos:	Lung cancer Cisplatin miR-493 TCRP1
Acesso em linha:	http://link.springer.com/article/10.1186/s13046-017-0582-5
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