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A chemogenetic approach for dopamine imaging with tunable sensitivity

Abstract Genetically-encoded dopamine (DA) sensors enable high-resolution imaging of DA release, but their ability to detect a wide range of extracellular DA levels, especially tonic versus phasic DA release, is limited by their intrinsic affinity. Here we show that a human-selective dopamine recept...

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Bibliografische gegevens
Hoofdauteurs: Marie A. Labouesse, Maria Wilhelm, Zacharoula Kagiampaki, Andrew G. Yee, Raphaelle Denis, Masaya Harada, Andrea Gresch, Alina-Măriuca Marinescu, Kanako Otomo, Sebastiano Curreli, Laia Serratosa Capdevila, Xuehan Zhou, Reto B. Cola, Luca Ravotto, Chaim Glück, Stanislav Cherepanov, Bruno Weber, Xin Zhou, Jason Katner, Kjell A. Svensson, Tommaso Fellin, Louis-Eric Trudeau, Christopher P. Ford, Yaroslav Sych, Tommaso Patriarchi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Portfolio 2024-07-01
Reeks:Nature Communications
Online toegang:https://doi.org/10.1038/s41467-024-49442-3
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