Particulate multivalent presentation of the receptor binding domain induces protective immune responses against MERS-CoV

Middle East respiratory syndrome coronavirus (MERS-CoV) is a WHO priority pathogen for which vaccines are urgently needed. Using an immune-focusing approach, we created self-assembling particles multivalently displaying critical regions of the MERS-CoV spike protein ─fusion peptide, heptad repeat 2,...

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Autori principali:	Nisreen M. A. Okba, Ivy Widjaja, Brenda van Dieren, Andrea Aebischer, Geert van Amerongen, Leon de Waal, Koert J. Stittelaar, Debby Schipper, Byron Martina, Judith M. A. van den Brand, Martin Beer, Berend-Jan Bosch, Bart L. Haagmans
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis Group 2020-01-01
Serie:	Emerging Microbes and Infections
Soggetti:	Vaccine MERS-coronavirus spike i301 lumazine synthase spytag-spycatcher
Accesso online:	https://www.tandfonline.com/doi/10.1080/22221751.2020.1760735
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