Molecular mechanism of vimentin nuclear localization associated with the migration and invasion of daughter cells derived from polyploid giant cancer cells

Abstract Background Polyploid giant cancer cells (PGCCs), a specific type of cancer stem cells (CSCs), can be induced by hypoxic microenvironments, chemical reagents, radiotherapy, and Chinese herbal medicine. Moreover, PGCCs can produce daughter cells that undergo epithelial–mesenchymal transition,...

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Hauptverfasser:	Linlin Fan, Minying Zheng, Xinyue Zhou, Yongjun Yu, Yidi Ning, Wenzheng Fu, Jing Xu, Shiwu Zhang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2023-10-01
Schriftenreihe:	Journal of Translational Medicine
Schlagworte:	Vimentin Polyploid giant cancer cells Colorectal cancer SUMOylation CDC42
Online-Zugang:	https://doi.org/10.1186/s12967-023-04585-7
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