A prognostic molecular signature of hepatic steatosis is spatially heterogeneous and dynamic in human liver

Summary: Hepatic steatosis is a central phenotype in multi-system metabolic dysfunction and is increasing in parallel with the obesity pandemic. We use a translational approach integrating clinical phenotyping and outcomes, circulating proteomics, and tissue transcriptomics to identify dynamic, func...

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Principais autores:	Andrew S. Perry, Niran Hadad, Emeli Chatterjee, Maria Jimenez-Ramos, Eric Farber-Eger, Rashedeh Roshani, Lindsey K. Stolze, Michael J. Betti, Shilin Zhao, Shi Huang, Liesbet Martens, Timothy J. Kendall, Tinne Thone, Kaushik Amancherla, Samuel Bailin, Curtis L. Gabriel, John Koethe, J. Jeffrey Carr, James Greg Terry, Nataraja Sarma Vaitinadin, Jane E. Freedman, Kahraman Tanriverdi, Eric Alsop, Kendall Van Keuren-Jensen, John F.K. Sauld, Gautam Mahajan, Sadiya S. Khan, Laura Colangelo, Matthew Nayor, Susan Fisher-Hoch, Joseph B. McCormick, Kari E. North, Jennifer E. Below, Quinn S. Wells, E. Dale Abel, Ravi Kalhan, Charlotte Scott, Martin Guilliams, Eric R. Gamazon, Jonathan A. Fallowfield, Nicholas E. Banovich, Saumya Das, Ravi Shah
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-12-01
coleção:	Cell Reports Medicine
Assuntos:	metabolic dysfunction-associated steatotic liver disease non-alcoholic fatty liver disease proteomics diabetes liver-on-a-chip
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2666379124006426
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