Effects of PCSK9 inhibitors on HDL cholesterol efflux and serum cholesterol loading capacity in familial hypercholesterolemia subjects: a multi-lipid-center real-world evaluation

Proprotein convertase subtilisin/kexin type 9 (PCSK9), beyond regulating LDL cholesterol (LDL-c) plasma levels, exerts several pleiotropic effects by modulating lipid metabolism in extrahepatic cells such as macrophages. Macrophage cholesterol homeostasis depends on serum lipoprotein functions, incl...

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Detalhes bibliográficos

Principais autores:	Marcella Palumbo, Antonina Giammanco, Francesco Purrello, Chiara Pavanello, Giuliana Mombelli, Antonino Di Pino, Salvatore Piro, Angelo Baldassare Cefalù, Laura Calabresi, Maurizio Averna, Franco Bernini, Francesca Zimetti, Maria Pia Adorni, Roberto Scicali
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-07-01
Colecção:	Frontiers in Molecular Biosciences
Assuntos:	PCSK9 inhibitors cholesterol efflux capacity cholesterol loading capacity familial hypercholesterolemia cardiovascular risk
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fmolb.2022.925587/full
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