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Emergence of a STAT3 mutated NK clone in LGL leukemia

Large granular lymphocyte (LGL) leukemia is a chronic clonal lymphoproliferative disorder. Here, a T-LGL leukemia patient developed NK-LGL leukemia with residual leukemic T-LGL. TCRVβ usage and CDR3 sequence drifts were observed with disease progression. A STAT3 S614R mutation was identified in NK b...

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Principais autores: Yiyi Yan, Thomas L. Olson, Susan B. Nyland, David J. Feith, Thomas P. Loughran Jr.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2015-01-01
Serier:Leukemia Research Reports
Fag:
Clonal evolution
T cell receptor
Classifications
Mutation detection
Leukemia markers
Online adgang:http://www.sciencedirect.com/science/article/pii/S2213048914000247
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