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Combined effect of esaxerenone and dapagliflozin on aldosterone-mediated sodium reabsorption and potassium excretion

IntroductionThe efficacy of nonsteroidal mineralocorticoid receptor blockers (MRBs) in inhibiting the progression of diabetic kidney disease (DKD) is well-known. However, MRB therapy often leads to hyperkalemia and remains a major concern. Recent studies suggest that combining potassium-retaining di...

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Hlavní autoři: Motonobu Nakamura, Nobuhiko Satoh, Tomohito Mizuno, Mayuko Takagi, Shoko Horita, Masaomi Nangaku
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2025-12-01
Edice:Frontiers in Physiology
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On-line přístup:https://www.frontiersin.org/articles/10.3389/fphys.2025.1677518/full
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