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DNA damage and repair: underlying mechanisms leading to microcephaly

DNA-damaging agents and endogenous DNA damage constantly harm genome integrity. Under genotoxic stress conditions, the DNA damage response (DDR) machinery is crucial in repairing lesions and preventing mutations in the basic structure of the DNA. Different repair pathways are implicated in the resol...

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Principais autores: Jessica Honorato Ribeiro, Nazlican Altinisik, Nicholas Rajan, Mieke Verslegers, Sarah Baatout, Jay Gopalakrishnan, Roel Quintens
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2023-10-01
coleção:Frontiers in Cell and Developmental Biology
Assuntos:
neurodevelopment
microcephaly
DNA damage
DNA repair pathways
DNA repair deficiency
ionizing radiation
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fcell.2023.1268565/full
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