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Discovery of a fragment hit compound targeting D-Ala:D-Ala ligase of bacterial peptidoglycan biosynthesis

Bacterial resistance is an increasing threat to healthcare systems, highlighting the need for discovering new antibacterial agents. An established technique, fragment-based drug discovery, was used to target a bacterial enzyme Ddl involved in the biosynthesis of peptidoglycan. We assembled general a...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Matic Proj, Martina Hrast, Gregor Bajc, Rok Frlan, Anže Meden, Matej Butala, Stanislav Gobec
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Taylor & Francis Group 2023-12-01
Rangatū:Journal of Enzyme Inhibition and Medicinal Chemistry
Ngā marau:
Urunga tuihono:https://www.tandfonline.com/doi/10.1080/14756366.2022.2149745
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