Fibrillar Inclusions and Motor Neuron Degeneration in Transgenic Mice Expressing Superoxide Dismutase 1 with a Disrupted Copper-Binding Site
Mutations in Cu/Zn superoxide dismutase 1 (SOD1) have been linked to dominantly inherited forms of amyotrophic lateral sclerosis (FALS). To test the hypothesis that the toxicity of mutant SOD1 originates in Cu2+-mediated formation of toxic radicals, we generated transgenic mice that express human SO...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Elsevier
2002-07-01
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| Col·lecció: | Neurobiology of Disease |
| Accés en línia: | http://www.sciencedirect.com/science/article/pii/S0969996102904985 |
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