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MicroRNAs in doxorubicin-induced cardiotoxicity: The DNA damage response

Doxorubicin (DOX) is a chemotherapeutic drug widely used for cancer treatment, but its use is limited by cardiotoxicity. Although free radicals from redox cycling and free cellular iron have been predominant as the suggested primary pathogenic mechanism, novel evidence has pointed to topoisomerase I...

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Principais autores: Ippei Kawano, Michaela Adamcova
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-11-01
coleção:Frontiers in Pharmacology
Assuntos:
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2022.1055911/full
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