Identification of Human Leukotriene A4 Hydrolase Inhibitors Using Structure-Based Pharmacophore Modeling and Molecular Docking

Leukotriene B4 (LTB4) is a potent, proinflammatory lipid mediator implicated in the pathologies of an array of inflammatory diseases and cancer. The biosynthesis of LTB4 is regulated by the leukotriene A4 hydrolase (LTA₄H). Compounds capable of limiting the formation of LTB4, through sele...

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Hlavní autoři:	Suaad A. Audat, Nizar A. Al-Shar’i, Buthina A. Al-Oudat, Amanda Bryant-Friedrich, Mel F. Bedi, Aref L. Zayed, Qosay A. Al-Balas
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2020-06-01
Edice:	Molecules
Témata:	leukotriene A4 hydrolase leukotriene B4 anti-cancer and anti-inflammatory agents pharmacophore modeling moelcular docking
On-line přístup:	https://www.mdpi.com/1420-3049/25/12/2871
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