Structural basis for hyperpolarization-dependent opening of human HCN1 channel

Abstract Hyperpolarization and cyclic nucleotide (HCN) activated ion channels are critical for the automaticity of action potentials in pacemaking and rhythmic electrical circuits in the human body. Unlike most voltage-gated ion channels, the HCN and related plant ion channels activate upon membrane...

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Autors principals:	Verena Burtscher, Jonathan Mount, Jian Huang, John Cowgill, Yongchang Chang, Kathleen Bickel, Jianhan Chen, Peng Yuan, Baron Chanda
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2024-06-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-024-49599-x
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