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Persistence of an Oncogenic Papillomavirus Genome Requires <italic toggle="yes">cis</italic> Elements from the Viral Transcriptional Enhancer

ABSTRACT Human papillomavirus (HPV) genomes are replicated and maintained as extrachromosomal plasmids during persistent infection. The viral E2 proteins are thought to promote stable maintenance replication by tethering the viral DNA to host chromatin. However, this has been very difficult to prove...

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Principais autores: Koenraad Van Doorslaer, Dan Chen, Sandra Chapman, Jameela Khan, Alison A. McBride
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017-12-01
Serier:mBio
Fag:
DNA replication
HPV
keratinocyte
papillomavirus
partitioning
persistent replication
Online adgang:https://journals.asm.org/doi/10.1128/mBio.01758-17
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