EpCAM-independent isolation of circulating tumor cells with epithelial-to-mesenchymal transition and cancer stem cell phenotypes using ApoStream® in patients with breast cancer treated with primary systemic therapy.

<h4>Background</h4>Tumor cells with a mesenchymal phenotype and/or cancer stem-like cells (CSCs) are known to contribute to metastasis and drug resistance. Circulating tumor cells (CTCs) undergoing epithelial-mesenchymal transition (EMT) and CTCs reflecting a dedifferentiated CSC phenotype may not b...

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Autori principali:	Fanny Le Du, Takeo Fujii, Kumiko Kida, Darren W Davis, Minjeong Park, Diane D Liu, Weiguo Wu, Mariana Chavez-MacGregor, Carlos H Barcenas, Vicente Valero, Debu Tripathy, James M Reuben, Naoto T Ueno
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Public Library of Science (PLoS) 2020-01-01
Serie:	PLoS ONE
Accesso online:	https://doi.org/10.1371/journal.pone.0229903
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