Cefepime Combined with Late-Generation β-Lactamase Inhibitors: Mechanisms of Action, In Vitro Activity, PK/PD Characteristics, Clinical Evidence and Resistance Mechanisms

Cefepime combined with late-generation β-lactamase inhibitors—enmetazobactam, zidebactam, and taniborbactam—represents a promising strategy to treat multidrug-resistant Gram-negative infections. These combinations expand the therapeutic armamentarium beyond established β-lactam/β-lactamase inhibitor...

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Detalhes bibliográficos

Principais autores:	Sara Comini, Matteo Boattini, Paolo Gaibani, Gabriele Bianco
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2026-03-01
coleção:	Antibiotics
Assuntos:	carbapenem sparing cefepime/enmetazobabtam cefepime/taniborbactam cefepime/zidebactam metallo-β-lactamase multi-drug-resistance
Acesso em linha:	https://www.mdpi.com/2079-6382/15/3/263
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