T Cell Exhaustion and Dendritic Cell‐Mediated Tertiary Lymphoid Structures (TLSs) Modulation Affect Response to Neoadjuvant Chemoradiotherapy in Microsatellite Stable Rectal Cancer

Abstract Locally advanced rectal cancer (LARC) presents significant treatment challenges, particularly in microsatellite stable (MSS) patients, who often show limited response to immunotherapy. In these cases, neoadjuvant chemoradiotherapy (neoCRT) followed by surgery remains the recommended approac...

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Главные авторы:	Miao Wang, Jiejun Shi, Kai Xu, Leyi Yu, Xiaomao Yin, Jiexuan Wang, Lin Zhu, Xin Yang, Jingjing Qian, Wenqiang Wang, Liangchen Zhu, Xuan Dai, Zekun Zhao, Jinran Wu, Dongsheng Li, Zhiqian Hu, Qi Huang, Xinxing Li
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Wiley 2026-01-01
Серии:	Advanced Science
Предметы:	early exhausted T cells locally advanced rectal cancer neoadjuvant chemoradiotherapy tertiary lymphoid structure
Online-ссылка:	https://doi.org/10.1002/advs.202514332
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