CDKAL1 dysfunction impairs lysine codon translation in podocytes and accelerates chronic kidney disease

Abstract Cdk5 regulatory subunit-associated protein 1-like 1 (Cdkal1) encodes a tRNA-modifying enzyme responsible for thiomethylation generating 2-methylthio-N 6-threonylcarbamoyladenosine (ms2t6A) in the anticodon loop of tRNALys UUU. Genome-wide association studies have identified CDKAL1 variants...

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Autors principals:	Hiroko Nagata, Yu Nagayoshi, Takeshi Chujo, Hitomi Kaneko, Kayo Nishiguchi, Yutaka Kakizoe, Hiroko Ijima, Korin Sakakida, Takeshi Masuda, Sumio Ohtsuki, Fan-Yan Wei, Yukie Takahashi, Takaichi Fukuda, Hideaki Jinnouchi, Yuki Adachi, Ryosuke Yamamura, Koki Matsushita, Masataka Adachi, Hideki Yokoi, Kimitoshi Nakamura, Hitoshi Nakazato, Kazuhito Tomizawa
Format:	Artigo
Idioma:	Inglês
Publicat:	Springer Nature 2026-03-01
Col·lecció:	The EMBO Journal
Matèries:	CDKAL1 Chronic Kidney Disease (CKD) tRNA Modification Enzyme Podocyte Dysfunction Lysine Codon Translation
Accés en línia:	https://doi.org/10.1038/s44318-026-00759-3
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