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LRP1 protects against excessive superior mesenteric artery remodeling by modulating angiotensin II–mediated signaling

Vascular smooth muscle cells (vSMCs) exert a critical role in sensing and maintaining vascular integrity. These cells abundantly express the low-density lipoprotein receptor–related protein 1 (LRP1), a large endocytic signaling receptor that recognizes numerous ligands, including apolipoprotein E–ri...

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Principais autores: Jackie M. Zhang, Dianaly T. Au, Hisashi Sawada, Michael K. Franklin, Jessica J. Moorleghen, Deborah A. Howatt, Pengjun Wang, Brittany O. Aicher, Brian Hampton, Mary Migliorini, Fenge Ni, Adam E. Mullick, Mashhood M. Wani, Areck A. Ucuzian, Hong S. Lu, Selen C. Muratoglu, Alan Daugherty, Dudley K. Strickland
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical investigation 2023-01-01
Serier:JCI Insight
Fag:
Vascular biology
Online adgang:https://doi.org/10.1172/jci.insight.164751
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