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Intensified Influenza Virus Production in Suspension HEK293SF Cell Cultures Operated in Fed-Batch or Perfusion with Continuous Harvest

Major efforts in the intensification of cell culture-based viral vaccine manufacturing focus on the development of high-cell-density (HCD) processes, often operated in perfusion. While perfusion operations allow for higher viable cell densities and volumetric productivities, the high perfusion rates...

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Principais autores: Cristina A. T. Silva, Amine A. Kamen, Olivier Henry
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-12-01
Serier:Vaccines
Fag:
influenza vaccine
process intensification
perfusion
fed-batch
suspension cells
high cell density
Online adgang:https://www.mdpi.com/2076-393X/11/12/1819
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