Predicting drug combination side effects based on a metapath-based heterogeneous graph neural network

Abstract In recent years, combined drug screening has played a very important role in modern drug discovery. Generally, synergistic drug combinations are crucial in treatment for many diseases. However, the toxic side effects of drug combinations are probably increased with the increase of drugs num...

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Hlavní autoři:	Leixia Tian, Qi Wang, Zhiheng Zhou, Xiya Liu, Ming Zhang, Guiying Yan
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2025-01-01
Edice:	BMC Bioinformatics
Témata:	Combinatorial drugs Side effect prediction Metapath Graph convolutional network Heterogeneous information network
On-line přístup:	https://doi.org/10.1186/s12859-024-06028-6
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