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Simvastatin Reduces Protection and Intestinal T Cell Responses Induced by a Norovirus P Particle Vaccine in Gnotobiotic Pigs

Noroviruses (NoVs) are a leading cause of acute gastroenteritis worldwide. P particles are a potential vaccine candidate against NoV. Simvastatin is a cholesterol-reducing drug that is known to increase NoV infectivity. In this study, we examined simvastatin’s effects on P particle-induced protectiv...

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Main Authors: Jacob Kocher, Tammy Bui Castellucci, Ke Wen, Guohua Li, Xingdong Yang, Shaohua Lei, Xi Jiang, Lijuan Yuan
Format: Artigo
Language:Inglês
Published: MDPI AG 2021-07-01
Series:Pathogens
Subjects:
simvastatin
human norovirus
P particle vaccine
gnotobiotic pig
T cells
protective efficacy
Online Access:https://www.mdpi.com/2076-0817/10/7/829
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