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Influenza Hemagglutinin Nanoparticle Vaccine Elicits Broadly Neutralizing Antibodies against Structurally Distinct Domains of H3N2 HA

Influenza vaccine effectiveness varies annually due to the fast evolving seasonal influenza A(H3N2) strain and egg-derived mutations—both of which can cause a mismatch between the vaccine and circulating strains. To address these limitations, we have developed a hemagglutinin (HA)-based protei...

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Principais autores: Alyse D. Portnoff, Nita Patel, Michael J. Massare, Haixia Zhou, Jing-Hui Tian, Bin Zhou, Vivek Shinde, Gregory M. Glenn, Gale Smith
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2020-02-01
Serier:Vaccines
Fag:
influenza
hemagglutinin
nanoparticle
vaccine
antibody
Online adgang:https://www.mdpi.com/2076-393X/8/1/99
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