Annexin A5 Inhibits Endothelial Inflammation Induced by Lipopolysaccharide-Activated Platelets and Microvesicles via Phosphatidylserine Binding

Sepsis is caused by a dysregulated immune response to infection and is a leading cause of mortality globally. To date, no specific therapeutics are available to treat the underlying septic response. We and others have shown that recombinant human annexin A5 (Anx5) treatment inhibits pro-inflammatory...

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Главные авторы:	Brent J. Tschirhart, Xiangru Lu, Janice Gomes, Arundhasa Chandrabalan, Gillian Bell, David A. Hess, Guangxin Xing, Hong Ling, Dylan Burger, Qingping Feng
Формат:	Artigo
Язык:	Inglês
Опубликовано:	MDPI AG 2023-06-01
Серии:	Pharmaceuticals
Предметы:	sepsis endotoxemia inflammation annexin A5 endothelial cells platelets
Online-ссылка:	https://www.mdpi.com/1424-8247/16/6/837
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