Dusp15 modulates mtHsp70 Thr116 phosphorylation state to preserve mito-UPR and attenuate cardiac dysfunction in diabetic cardiomyopathy

Abstract Background Diabetic cardiomyopathy (DCM) involves cardiac dysfunction/remodeling with mitochondrial stress and impaired mitochondrial proteostasis. The role of dual-specificity phosphatases (DUSPs) in these processes remains unclear. We examined whether Dusp15 modulates diabetic cardiac inj...

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Principais autores:	Yan Liu, Hongshuo Shi, Chun Li, Haowen Zhuang, Yinglong Li, Xiuling He, Ying Jiang, Zhiyu Jin, Zhijiang Guo, Sangbing Ong, Yuanyuan Wang, Xing Chang, Guipeng An, Junyan Wang
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2026-03-01
Series:	Cardiovascular Diabetology
Assuntos:	Diabetic cardiomyopathy Dusp15 mtHsp70 Mitochondrial unfolded protein response
Acceso en liña:	https://doi.org/10.1186/s12933-026-03125-z
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