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Trinucleotide Repeats: A structural perspective

Trinucleotide repeat (TNR) expansions are present in a wide range of genes involved in several neurological disorders, being directly involved in the molecular mechanisms underlying pathogenesis through modulation of gene expression and/or the function of the RNA or protein it encodes. Structural an...

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Principais autores: Bruno eAlmeida, Sara eFernandes, Isabel A. Abreu, Sandra eMacedo-Ribeiro
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2013-06-01
Serier:Frontiers in Neurology
Fag:
Amyloid
protein aggregation
Protein complexes
protein structure
microsatellites
Amino acid repeats
Online adgang:http://journal.frontiersin.org/Journal/10.3389/fneur.2013.00076/full
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