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Encephalopathy in mechanically ventilated adult patients in the intensive care unit: the role of β-Lactam overdosing

Abstract Delirium is common in ICU and the neurotoxicity induced by antibiotics could be at least in part responsible for it. This study explored the association between β-Lactam overdosing and persistent coma or delirium in patients under mechanical ventilation. All adult patients admitted in ICU r...

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Principais autores: Ségolène Gendreau, Brice Benelli, Guillaume Cintrat, Etienne Dufranc, Romain Arrestier, Pierre Bay, Louise Chantelot, Pascale Labedade, Elsa Moncomble, Guillaume Carteaux, Nicolas de Prost, Anne Hulin, Claire Pressiat, Armand Mekontso Dessap, Keyvan Razazi, ADEL study group
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2026-02-01
Serier:Scientific Reports
Fag:
Delirium
Coma
Antibiotics
Therapeutic drug monitoring
Encephalopathy
Neurotoxicity
Online adgang:https://doi.org/10.1038/s41598-026-38709-y
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