Metabolic and Pharmacokinetic Profiling Studies of N, N-Dimethylaniline-Heliamine in Rats by UHPLC-Q-Orbitrap MS/MS

Cardiovascular disease is the first cause of death worldwide and kills more people each year than any other cause of death. N, N-dimethylaniline-heliamine (DH), a synthetic tetrahydroisoquinoline alkaloid, has shown notable antiarrhythmic activity. However, the metabolic processes and pharmacokineti...

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Hauptverfasser:	Ruqi Xi, Rahima Abdulla, Jurakulov Sherzod, Vinogradova Valentina Ivanovna, Maidina Habasi, Yongqiang Liu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2024-09-01
Schriftenreihe:	Molecules
Schlagworte:	N, N-dimethylheliamine pharmacokinetics metabolites UHPLC-MS/MS rats antiarrhythmic
Online-Zugang:	https://www.mdpi.com/1420-3049/29/18/4324
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