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Recombinant high-density lipoprotein targeted delivery of celastrol to promote foam cells lipophagy against early atherosclerosis

Abstract Introduction Atherosclerosis serving as the main underlying factor of cardiovascular disease (CVD) remains the primary cause of mortality and morbidity globally, while the deposition of massive cholesterol in macrophage-derived foam cells exerts pivotal roles in the occurrence and progressi...

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Autori principali: Yang Li, Xiaoxia Xue, Liuchunyang Yu, Jinxiu Qian, Xiaoyu Li, Meng Tian, Jue Yang, Rongjun Deng, Cheng Lu, Cheng Xiao, Yuanyan Liu
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2025-03-01
Serie:Journal of Nanobiotechnology
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Accesso online:https://doi.org/10.1186/s12951-025-03327-9
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