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Altered development of dopaminergic neurons differentiated from stem cells from human exfoliated deciduous teeth of a patient with Down syndrome

Abstract Background Down syndrome (DS) is a common developmental disorder resulting from the presence of an additional copy of chromosome 21. Abnormalities in dopamine signaling are suggested to be involved in cognitive dysfunction, one of the symptoms of DS, but the pathophysiological mechanism has...

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Principais autores: Thanh Thi Mai Pham, Hiroki Kato, Haruyoshi Yamaza, Keiji Masuda, Yuta Hirofuji, Hiroshi Sato, Huong Thi Nguyen Nguyen, Xu Han, Yu Zhang, Tomoaki Taguchi, Kazuaki Nonaka
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2018-08-01
coleção:BMC Neurology
Assuntos:
Down syndrome
Dopamine
Human exfoliated deciduous teeth
SHED
Stem cells
Dopaminergic neurons
Acesso em linha:http://link.springer.com/article/10.1186/s12883-018-1140-2
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