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cTnIR193H restrictive cardiomyopathy mice satisfy high-energy metabolic demands through regulating glucose metabolism

This work aims to investigate the energy metabolism in mice with restrictive cardiomyopathy induced by cardiac troponin I (cTnI) R193H mutation. Echocardiography was used to monitor cardiac function. ATP content and ATPase activity were detected with relevant kits. The expression levels of GLUT4, FA...

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Principais autores: Min Luo, Lingjuan Liu, Wenjing Yuan, Junjun Quan, Mi Li, Jie Tian
Format: Artigo
Sprog:Inglês
Udgivet: KeAi Communications Co., Ltd. 2026-03-01
Serier:Genes and Diseases
Fag:
cTnIR193H mutation
Glucose and fatty acid intake
Glucose metabolism
PI3K/Akt
Restrictive cardiomyopathy
Online adgang:http://www.sciencedirect.com/science/article/pii/S2352304225002739
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