The Deficiency of Indoleamine 2,3-Dioxygenase Aggravates the CCl4-Induced Liver Fibrosis in Mice.

In the present study, we examined the role of indoleamine 2,3-dioxygenase (IDO) in the development of CCl4-induced hepatic fibrosis. The liver fibrosis induced by repetitive administration with CCl4 was aggravated in IDO-KO mice compared to WT mice. In IDO-KO mice treated with CCl4, the number of se...

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Bibliografische Detailangaben

Hauptverfasser:	Hideyuki Ogiso, Hiroyasu Ito, Tatsuya Ando, Yuko Arioka, Ayumu Kanbe, Kazuki Ando, Tetsuya Ishikawa, Kuniaki Saito, Akira Hara, Hisataka Moriwaki, Masahito Shimizu, Mitsuru Seishima
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Public Library of Science (PLoS) 2016-01-01
Schriftenreihe:	PLoS ONE
Online-Zugang:	http://europepmc.org/articles/PMC5012673?pdf=render
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