Deciphering the decisive factors driving fate bifurcations in somatic cell reprogramming

Single-cell studies have demonstrated that somatic cell reprogramming is a continuous process of cell fates transition. Only partial reprogramming intermediates can overcome the molecular bottlenecks to acquire pluripotency. To decipher the underlying decisive factors driving cell fate, we identifie...

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Autori principali:	Chunshen Long, Hanshuang Li, Pengfei Liang, Lemuge Chao, Yan Hong, Junping Zhang, Qilemuge Xi, Yongchun Zuo
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2023-12-01
Serie:	Molecular Therapy: Nucleic Acids
Soggetti:	MT: Bioinformatics somatic cell reprogramming cellular trajectory gene regulatory network fate bifurcation decisive factors
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2162253123002627
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