Insulin-like Growth Factor-1 Prevents Hypoxia/Reoxygenation-Induced White Matter Injury in Sickle Cell Mice

Occlusion of cerebral blood vessels causes acute cerebral hypoxia—an important trigger of ischemic white matter injury and stroke in sickle cell disease (SCD). While chronic hypoxia triggers compensatory neuroprotection via insulin-like growth factor-1 (IGF-1) and hypoxia inducible factor-1α (HIF-1α...

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Principais autores:	Rimi Hazra, Holland Hubert, Lynda Little-Ihrig, Samit Ghosh, Solomon Ofori-Acquah, Xiaoming Hu, Enrico M Novelli
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2023-02-01
coleção:	Biomedicines
Assuntos:	sickle cell disease hypoxia inducible factor-1α insulin-like growth factor 1 white matter injury hypoxia stroke
Acesso em linha:	https://www.mdpi.com/2227-9059/11/3/692
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