An adaptive stress response that confers cellular resilience to decreased ubiquitination

Abstract Ubiquitination is a post-translational modification initiated by the E1 enzyme UBA1, which transfers ubiquitin to ~35 E2 ubiquitin-conjugating enzymes. While UBA1 loss is cell lethal, it remains unknown how partial reduction in UBA1 activity is endured. Here, we utilize deep-coverage mass s...

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Detalles Bibliográficos

Principais autores:	Liam C. Hunt, Vishwajeeth Pagala, Anna Stephan, Boer Xie, Kiran Kodali, Kanisha Kavdia, Yong-Dong Wang, Abbas Shirinifard, Michelle Curley, Flavia A. Graca, Yingxue Fu, Suresh Poudel, Yuxin Li, Xusheng Wang, Haiyan Tan, Junmin Peng, Fabio Demontis
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2023-11-01
Series:	Nature Communications
Acceso en liña:	https://doi.org/10.1038/s41467-023-43262-7
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